Category Archives: Uncategorized

How did this anti-nausea drug cause thousands of birth defects? On the Curious Clinicians, we like to often discuss more lighthearted topics, such as why some people think cilantro tastes like soap or whether the post-Thanksgiving turkey coma is a real thing. This episode deals with something whose pathophysiology and history are considerably darker, butContinue reading “Episode 83 – Thalidomide Embryopathy”

Why don’t we transfuse to a normal hemoglobin? Patients are so much more than numbers on a chart, but those numbers really are important. Lab values like potassium and white blood cells are not just figures to be balanced like there’s an impending IRS audit – they give quantifiable information on how a patient isContinue reading “Episode 82 – When Normal Labs Aren’t Necessary”

How does sickle cell trait protect against malaria infection and mortality? In any medical genetics course, sickle cell trait (SCT) and sickle cell disease (SCD) are sure to be brought up early and often. They follow an easily-understood inheritance pattern and can be used as examples in teaching biochemistry basics such as protein folding andContinue reading “Episode 81 – Avoiding Malaria”

Why do we use ACE inhibitors to treat scleroderma renal crisis? In a day of seeing adult patients in any type of clinic, it’d be hard to not hear the words “ACE inhibitor” at least once. Since the introduction of captopril in the mid-1970s and subsequent family members like lisinopril, ACE inhibitors have been gameContinue reading “Episode 80 – A Scleroderma Crisis”

Why can a ketogenic diet help control seizures in epilepsy? Many forms of dietary therapy make intuitive sense. 18th-century sailors with scurvy were treated with lime juice and other sources of the missing vitamin C. Patients with diabetes mellitus are counseled to avoid foods with a high glycemic index. And those with chylothoraces, where aContinue reading “Episode 79 – Kurious Keto”