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Why do diseases present in certain ways? What are the mechanisms of treatments we use? Why does the human body function as it does?

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Episode List

Episode 131: A President’s Polio

Did President Franklin Delano Roosevelt truly have polio, or is an alternate diagnosis more likely? Over time, some narratives in medical history become regarded as settled truth, despite being a great deal more nuanced. Saying that Edward Jenner “invented vaccines” or that penicillin was the “first antibiotic” isn’t false so much as it’s incomplete. On…

130 – The Simp with Dr. Roshan Sethi

The Curious Clinicians were thrilled to have Dr. Roshan Sethi, a practicing radiation oncology physician, television and film screenwriter, director, producer and novelist on the show. Roshan’s incisive, hilarious, insightful, and extraordinarily honest debut novel The Simp, which takes a hard look at the underbelly of Hollywood culture, was published in July 2026. In our…

Episode 129: Ironing Out More Platelets

Why does iron deficiency cause thrombocytosis? The differential for thrombocytopenia, or low platelets, is a classic. Are all the cell lines down? Usually bone marrow suppression due to anything from leukemia to Lyme disease. Is there new, severe thrombocytopenia and anemia? Make sure to rule out a microangiopathic hemolytic anemia (MAHA). Is there portal hypertension…

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Disclaimer: Content does not represent medical advice or the views of any institution with which the authors are affiliated.


Cover photo by Josh Redd on Unsplash