Why do diseases present in certain ways? What are the mechanisms of treatments we use? Why does the human body function as it does?
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Episode List
Episode 123 – Why-roid
“Whyroid” – Why does an autoimmune antibody stimulate the thyroid in Graves’ disease? When we think of antibodies, such as monoclonal antibodies that target specific diseases, we often think of them as blocking receptor-ligand interactions or binding to pathogens to neutralize them. Yet in Graves’ disease, we actually find the opposite of what we would…
Episode 122 – When CRP goes missing
Why do patients with active lupus have a low CRP? Although the erythrocyte sedimentation rate (ESR) is typically high in active lupus, C-reactive protein (CRP) is often normal. What’s particularly cool about this finding is that it lends insights into the mechanism of lupus and potentially its cause. The earliest report alluding to this discordance…
Episode 121 – The Forgotten Factor
Why doesn’t factor 12 deficiency cause bleeding? In July 1953, freight brakeman John Hageman’s doctors faced a scenario that might feel familiar to anyone who has ever done preoperative medicine consults. Hageman had planned to undergo a partial gastrectomy for peptic ulcer disease, but his preoperative tests showed a prolonged clotting time. In the 1950s,…
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