Why do diseases present in certain ways? What are the mechanisms of treatments we use? Why does the human body function as it does?
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Episode List
Episode 122 – When CRP goes missing
Why do patients with active lupus have a low CRP? Although the erythrocyte sedimentation rate (ESR) is typically high in active lupus, C-reactive protein (CRP) is often normal. What’s particularly cool about this finding is that it lends insights into the mechanism of lupus and potentially its cause. The earliest report alluding to this discordance…
Episode 121 – The Forgotten Factor
Why doesn’t factor 12 deficiency cause bleeding? In July 1953, freight brakeman John Hageman’s doctors faced a scenario that might feel familiar to anyone who has ever done preoperative medicine consults. Hageman had planned to undergo a partial gastrectomy for peptic ulcer disease, but his preoperative tests showed a prolonged clotting time. In the 1950s,…
Episode 120 – No Sleep for the Weary
Why can’t people with familial fatal insomnia fall asleep? Have you ever wondered why you feel so awful when you don’t get enough sleep? Well, that’s because it is no exaggeration when we say we need sleep to survive, so much so that we spend approximately ⅓ of our lives sleeping. Insomnia can certainly feel…
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Disclaimer: Content does not represent medical advice or the views of any institution with which the authors are affiliated.
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